Safety evaluation of lasalocid use in farm-reared pheasants

................................................................................................................... vi CHAPTER 1. GENERAL INTRODUCTION AND LITERATURE REVIEW ..............1 Thesis Organization...................................................................................................... 1 Literature Review ......................................................................................................... 1 Pheasant background ................................................................................................ 1 Coccidiosis................................................................................................................ 3 Classification of pheasants ....................................................................................... 5 Extra-label drug use (ELDU) ................................................................................... 5 Ionophores ................................................................................................................ 6 Lasalocid ................................................................................................................... 7 Lasalocid toxicity ..................................................................................................... 7 Current use of lasalocid ............................................................................................ 9 FDA drug approval process .................................................................................... 10 Investigational new animal drug (INAD) exemption ............................................. 11 New animal drug application (NADA) information ............................................... 12 Conclusion .................................................................................................................. 14 CHAPTER 2. SAFETY EVALUATION OF LASALOCID USE IN RING NECKED PHEASANTS (PHASIANUS COLCHICUS) .................................................................17 Abstract ...................................................................................................................... 17 Introduction ................................................................................................................ 18 Materials and Methods ............................................................................................... 19 Results ........................................................................................................................ 24..................................................................................................................... 17 Introduction ................................................................................................................ 18 Materials and Methods ............................................................................................... 19 Results ........................................................................................................................ 24